Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities
Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities
Emmanuel Chinedu Nnadi,Vivian Ifeoma Okonkwo,Chidinma Eucharia Ikwelle,Faith Temitope Elijah,Anulika Ruphina Phil-Mba,Vivian Chinenye Odo,Blessing Ginika Eke
Department of Science Laboratory Technology, University of Nigeria, Nsukka Department of Chemistry, University of Iowa, USA (Nigeria)
Department of Science Laboratory Technology, University of Nigeria, Nsukka (Nigeria)
Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka (Nigeria)
Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka (Nigeria)
Department of Pharmacy, University of Nigeria, Nsukka (Nigeria)
Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka (Nigeria)
Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka (Nigeria)
Publication Information
Journal Title: International Journal of Research and Scientific Innovation (IJRSI)
Author(s):Nnadi,Emmanuel Chinedu ;Okonkwo,Vivian Ifeoma ;Ikwelle,Chidinma Eucharia ;Elijah,Faith Temitope ;Phil-Mba,Anulika Ruphina ;Odo,Vivian Chinenye ;Ginika,Blessing Eke
Published On: 10/31/2025
Volume: 12
Issue: 9
First Page: 2584
Last Page: 2610
ISSN: 2321-2705
- Cite this Article Nnadi,Emmanuel Chinedu ;Okonkwo,Vivian Ifeoma ;Ikwelle,Chidinma Eucharia ;Elijah,Faith Temitope ;Phil-Mba,Anulika Ruphina ;Odo,Vivian Chinenye ;Ginika,Blessing Eke; Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities, Volume 12 Issue 9, International Journal of Research and Scientific Innovation (IJRSI),2584-2610, Published on 10/31/2025, Available at https://rsisinternational.org/journals/ijrsi/article.php?id=244#:~:text=Due%20to%20the%20unfading%20therapeutic,convulsant%2C%20anti%2Dcancer%20anti%2D
Abstract
Quinoline compounds and their derivatives have a vast distribution in nature coupled with their immense therapeutic potential. Due to the unfading therapeutic benefits of these compounds over the years, a lot of researchers are exploring the synthesis of various derivatives of quinoline which are screened for different therapeutic activities including, anti-malarial, anti-microbial, anti-inflammatory, anti-convulsant, anti-cancer anti-mycobacterial, cardio-protective, neuroprotective activity etc. This review highlights various advances in the synthetic routes and methodology for some quinoline derivatives including Friedlander modified metal-catalyzed reactions, Photo-induced oxidative annulation reaction, Microwave-assisted doebner reaction and their biological properties.
Keywords:
Quinolines, Derivatives, Synthetic routes, biological properties
