Unraveling the Therapeutic Role of Myoinositol in Polycystic Ovary Syndrome
Unraveling the Therapeutic Role of Myoinositol in Polycystic Ovary Syndrome
Malak Shariff*1, Dr. Mamta Saraf2, Valanka Melicia Fernandes3, Zoya Sadaf4, Bhalavikashini D R5, Sai Krishna Mohana Kondra6, Rohan K7, Samuel Bilgates Brettlee8
1Department of Cardiac Care Technology, Jain University, Bengaluru, Karnataka, India
2Department of Clinical Diagnostics, Jain University, Aurangabad, Maharashtra, India
3Department of Psychology, Jain University, Shiroda, Goa, India
4Department of Psychology, Jain University, Ramnagar, Karnataka, India
5Department of Psychology, Jain University, Bengaluru, Karnataka, India
6Department of Psychology, Jain University, Rajamahendravaram, Andhra Pradesh, India
7Department of Cardiac Care Technology, Jain University, Bengaluru, Karnataka, India
8Department of Psychology, Jain University, Bengaluru, Karnataka, India
Publication Information
Journal Title: International Journal of Research and Scientific Innovation (IJRSI)
Author(s): Shariff, Malak; Saraf, Dr. Mamta; Fernandes, Valanka Melicia; Sadaf,Zoya; D R, Bhalavikashini; Kondra, Sai Krishna Mohana; K, Rohan; Brettlee, Samuel Bilgates
Published On: 07/10/2025
Volume: 12
Issue: 4
First Page: 1360
Last Page: 1373
ISSN: 2321-2705
Cite this Article Shariff, Malak; Saraf, Dr. Mamta; Fernandes, Valanka Melicia; Sadaf,Zoya; D R, Bhalavikashini; Kondra, Sai Krishna Mohana; K, Rohan; Brettlee, Samuel Bilgates; Unraveling the Therapeutic Role of Myoinositol in Polycystic Ovary Syndrome, Volume 12 Issue 4, International Journal of Research and Scientific Innovation (IJRSI), 1360-1373, Published on 05/17/2025, Available at https://rsisinternational.org/journals/ijrsi/articles/unraveling-the-therapeutic-role-of-myoinositol-in-polycystic-ovary-syndrome/
Abstract
Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder affecting a significant number of women of reproductive age. It is characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovaries, contributing to infertility and metabolic disturbances. Inositol, particularly myo-inositol (MI), has emerged as a promising therapeutic approach for managing PCOS symptoms. Myo-inositol is an essential component of cell membranes and a precursor to several important signaling pathways. Recent studies have highlighted its beneficial effects on insulin sensitivity, ovarian function, and hormonal regulation in women with PCOS. This review states the potential mechanisms through which myo-inositol modulates insulin resistance, a key metabolic feature of PCOS, and its impact on ovarian function, including its role in improving oocyte quality and promoting regular menstrual cycles. Furthermore, the combination of myo-inositol with D-chiro-inositol (DCI) has been studied for its synergistic effects in managing PCOS symptoms. By evaluating the current literature, this review provides insights into the clinical efficacy of myo-inositol as a safe and effective adjunct in the management of PCOS, with particular emphasis on its role in restoring metabolic balance and improving reproductive outcomes. The review also discusses the challenges and areas for future research to further elucidate the optimal dosing, treatment regimens, and long-term outcomes of myo-inositol therapy for PCOS.
Keywords: Myoinositol, PCOS, Insulin Resistance, Hirsutism, Fertility management
